Detonation pulse engine

Exploratory experiments with an air-breathing propulsion device which uses detonative combustion to achieve high cycle pressures, are reported. In the first phase, detonation in a chamber containing ethylene and air was initiated by a detonation produced in a small tube containing ethylene and oxygen. An automobile spark system was used for ignition. In the second phase, a repetitive detonation process was sustained in a naturally-aspirated chamber at a frequency of 25Hz. Projections based on the present test results suggest that frequencies of 150Hz and specific impulse in the range 1000-1400 sec might be obtained in a practical engine.Office of Naval Research via Naval Postgraduate School Foundation Research Progra

A Randomized Parallel Sorting Algorithm With an Experimental Study

Previous schemes for sorting on general-purpose parallel machines have had to choose between poor load balancing and irregular communication or multiple rounds of all-to-all personalized communication. In this paper, we introduce a novel variation on sample sort which uses only two rounds of regular all-to-all personalized communication in a scheme that yields very good load balancing with virtually no overhead. Moreover, unlike previous variations, our algorithm efficiently handles the presence of duplicate values without the overhead of tagging each element with a unique identifier. This algorithm was implemented in Split-C and run on a variety of platforms, including the Thinking Machines CM-5, the IBM SP-2, and the Cray Research T3D. We ran our code using widely different benchmarks to examine the dependence of our algorithm on the input distribution. Our experimental results illustrate the efficiency and scalability of our algorithm across different platforms. In fact, it seems to..

Down Syndrome, Beta-Amyloid and Neuroimaging

This review focuses on the role of Aβ in AD pathogenesis in Down syndrome and current approaches for imaging Aβ in vivo. We will describe how Aβ deposits with age, the posttranslational modifications that can occur, and detection in biofluids. Three unique case studies describing partial trisomy 21 cases without APP triplication, and the occurrences of low level mosaic trisomy 21 in an early onset AD patient are presented. Brain imaging for Aβ includes those by positron emission tomography and ligands (Pittsburgh Compound B, Florbetapir, and FDDNP) that bind Aβ have been published and are summarized here. In combination, we have learned a great deal about Aβ in DS in terms of characterizing age of onset of this pathology and it is exciting to note that there is a clinical trial in DS targeting Aβ that may lead to clinical benefits

Designing Practical Efficient Algorithms for Symmetric Multiprocessors

Symmetric multiprocessors (SMPs) dominate the high-end server market and are currently the primary candidate for constructing large scale multiprocessor systems. Yet, the design of efficient parallel algorithms for this platform currently poses several challenges. In this paper, we present a computational model for designing efficient algorithms for symmetric multiprocessors. We then use this model to create efficient solutions to two widely different types of problems - linked list prefix computations and generalized sorting. Our novel algorithm for prefix computations builds upon the sparse ruling set approach of Reid-Miller and Blelloch. Besides being somewhat simpler and requiring nearly half the number of memory accesses, we can bound our complexity with high probability instead of merely on average. Our algorithm for generalized sorting is a modification of our algorithm for sorting by regular sampling on distributed memory architectures. The algorithm is a stable sort which appears to be asymptotically faster than any of the published algorithms for SMPs. Both of our algorithms were implemented in C using POSIX threads and run on three symmetric multiprocessors - the DEC AlphaServer, the Silicon Graphics Power Challenge, and the HP-Convex Exemplar. We ran our code for each algorithm using a variety of benchmarks which we identified to examine the dependence of our algorithm on memory access patterns. In spite of the fact that the processors must compete for access to main memory, both algorithms still yielded scalable performance up to 16 processors, which was the largest platform available to us. For some problems, our prefix computation algorithm actually matched or exceeded the performance of the best sequential solution using only a single thread. Similarly, our generalized sorting algorithm always beat the performance of sequential merge sort by at least an order of magnitude, even with a single thread. (Also cross-referenced as UMIACS-TR-98-44

Sorting on Clusters of SMPs

Clusters of symmetric multiprocessors (SMPs) have emerged as the primary candidates for large scale multiprocessor systems. In this paper, we introduce an efficient sorting algorithm for clusters of SMPs. This algorithm relies on a novel scheme for stably sorting on a single SMP coupled with balanced regular communication on the cluster. Our SMP algorithm seems to be asymptotically faster than any of the published algorithms we are aware of. The algorithms were implemented in C using Posix Threads and the SIMPLE library of communication primitives and run on a cluster of DEC AlphaServer 2100A systems. Our experimental results verify the scalability and efficiency of our proposed solution and illustrate the importance of considering both memory hierarchy and the overhead of shifting to multiple nodes. (Also cross-reference as UMIACS-TR-97-6

Practical Parallel Algorithms for Personalized Communication and Integer Sorting

A fundamental challenge for parallel computing is to obtain high-level, architecture independent, algorithms which efficiently execute on general-purpose parallel machines. With the emergence of message passing standards such as MPI, it has become easier to design efficient and portable parallel algorithms by making use of these communication primitives. While existing primitives allow an assortment of collective communication routines, they do not handle an important communication event when most or all processors have non-uniformly sized personalized messages to exchange with each other. We focus in this paper on the h-relation personalized communication whose efficient implementation will allow high performance implementations of a large class of algorithms. While most previous h-relation algorithms use randomization, this paper presents a new deterministic approach for h-relation personalized communication. As an application, we present an efficient algorithm for stable integer sorting. The algorithms presented in this paper have been coded in Split-C and run on a variety of platforms, including the Thinking Machines CM-5, IBM SP-1 and SP-2, Cray Research T3D, Meiko Scientific CS-2, and the Intel Paragon. Our experimental results are consistent with the theoretical analysis and illustrate the scalability and efficiency of our algorithms across different platforms. In fact, they seem to outperform all similar algorithms known to the authors on these platforms. (Also cross-referenced as UMIACS-TR-95-101.

Phase II Study of Sequential Gemcitabine Followed by Docetaxel for Recurrent Ewing Sarcoma, Osteosarcoma, or Unresectable or Locally Recurrent Chondrosarcoma: Results of Sarcoma Alliance for Research Through Collaboration Study 003

Background.Gemcitabine and docetaxel have a broad spectrum of clinical activity in patients with carcinoma. The Sarcoma Alliance for Research Through Collaboration conducted a phase II trial of gemcitabine in combination with docetaxel in children and adults with recurrent Ewing sarcoma (EWS), osteosarcoma (OS), or unresectable or recurrent chondrosarcoma. The primary objective was to determine the objective response rate using Response Evaluation Criteria in Solid Tumors (RECIST).Methods.Gemcitabine (675 mg/m2 i.v. over 90 minutes on days 1 and 8) was administered in combination with docetaxel (75 mg/m2 i.v. over 1 hour on day 8) every 21 days. All patients received filgrastim or pegfilgrastim. A Bayesian formulation was used to determine the probability of achieving the target response rate for each subtype—0.35 for EWS and OS or 0.20 for chondrosarcoma. If the probability of achieving the target response rate was <0.05, the combination was considered inactive. Toxicity was graded according to Common Terminology Criteria for Adverse Events (CTCAE), version 3.0.Results.Fifty‐three eligible patients were enrolled in the three subtype groups—OS (n = 14), EWS (n = 14), and chondrosarcoma (n = 25). Toxicities included neutropenia, thrombocytopenia, fatigue, dyspnea, bronchospasm, edema, neuropathy, and liver function abnormalities. Dose modification for toxicity was required for eight patients during cycle 1 and 16 patients in subsequent cycles. Seven patients withdrew from therapy as a result of toxicity. No complete responses were observed. Partial responses were observed in OS (n = 1), EWS (n = 2), and chondrosarcoma (n = 2) patients.Conclusion.Gemcitabine in combination with docetaxel was associated with a probability of reaching the target 35% response rate of <5% in OS patients and 5.6% in EWS patients; the probability of reaching a 20% response rate in chondrosarcoma patients was 14%.摘要背景. 吉西他滨与多西他赛对癌症患者有广谱的临床疗效。 肉瘤研究联盟协作组在复发的尤文肉瘤 （EWS）、 骨肉瘤 （OS）、 不可切除或复发的软骨肉瘤成人和儿童患者中开展了吉西他滨联合多西他赛的 II 期试验。 主要目的为通过实体瘤疗效评估标准 （RECIST） 确定客观缓解率。方法. 吉西他滨 （675 mg/m2， 静脉滴注 90 分钟以上， 第 1 和 8 天） 联合多西他赛 （75 mg/m2， 静脉滴注 1 小时以上， 第 8 天） 每 21 天给药 1 次。 全部患者均同时接受非格司亭或乙二醇化非格司亭。 利用贝叶斯公式来确定各个亚型达到目标缓解率的概率——EWS 和 OS 为 0.35， 软骨肉瘤为 0.20。 如果达到目标缓解率的概率 < 0.05， 则认为联合方案无效。 毒性反应根据不良事件通用术语标准 （CTCAE） 3.0 版来分级。结果. 53 例合格患者入组 3 个亚型组 ： OS （n=14）、 EWS （n=14）、 软骨肉瘤 （n=25）。 毒性反应包括中性粒细胞减少、 血小板减少、 乏力、 呼吸困难、 支气管痉挛、 水肿、 神经病变以及肝功能异常。 第 1 个周期有 8 例患者、 其后周期有 16 例患者因毒性反应而需要剂量调整。 7 例患者因毒性反应而撤出治疗。 未观察到完全缓解。 OS （n=1）、 EWS （n=2） 和软骨肉瘤 （n=2） 组均有患者达到部分缓解。结论. 吉西他滨联合多西他赛在 < 5% 的 OS 患者、 5.6% 的 EWS 患者中达到目标缓解率的概率为 35%； 14% 软骨肉瘤患者中达到目标缓解率的概率为 20%。讨论. 贝叶斯公式能够评估各个亚型在分别进行缓解率评估后预测达到目标缓解率的概率。 通过多角度来看这些数据， 在考量达到目标缓解率的概率以及入组率之后即能发现本研究设计方案阻碍了研究的继续开展。 因为这一设计方案并未设定判断治疗为 “有效” 的规则， 所以并不适合与标准的分 2 阶段进行的 II 期试验设计直接比较。 关闭 EWS 和软骨肉瘤亚组的决定， 某种程度上是基于入组缓慢， 另外达到目标缓解率的概率较低也支持这一决定。 入组率而不是统计设计， 对试验周期有显著影响。The Oncologist 2012;17:321‐e329Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/139909/1/onco0321-sup-0002.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139909/2/onco0321-sup-0001.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/139909/3/onco0321.pd

Annotated Bibliography of Research in the Teaching of English (2009)

This is the publisher's version, also found at http://search.proquest.com/docview/215343848/13E80C2B60056B43EE4/5?accountid=1455

Annotated Bibliography of Research in the Teaching of English (2007)

This is the publisher's version, also found at http://search.proquest.com/docview/215344428?accountid=14556The young women established bonds through nonverbal communication (e.g., eye gaze) to assert their gendered, racial, and cultural identities in the face of dominant identities promoted in the classroom. Draws on research with a diverse group of high school students to demonstrate how portraiture and CRT work together to render rich descriptions of students' experiences within their social and political contexts that serve the larger goal of social action and transformation. Examines the discourse practices of two immigrant youth who use Internet communication to mobilize transnational diasporic identities, create affinity spaces across geopolitical borders, and creatively produce and consume popular media. Uses Critical Race Theory, whiteness studies, and critical discourse analysis to understand talk about race among second-grade white students and their teachers. Through comparison of text choice, vocabulary, and comprehension and composition activities in each context, the regular reading class emerged as student-centered, whereas the reading intervention class was test-driven with less student participation